| Abstract: | ![]()
The EtOH extract of dried root bark of Tripterygium wilfordii Hook. f. (Celastraceae) afforded a novel macrolactone cyclopeptide named triptotin L (=cyclo[L ‐alanyl‐L ‐alanyl‐3‐(4,4,9‐trimethyldecyl‐3‐hydroxypropanoylglycyl‐L ‐valyl‐L ‐leucyl; 1 ), the new triterpene 2β,6α,22β‐trihydroxy‐24,29‐dinor‐D:A‐friedoolean‐4‐ene‐3,21‐dione named 6α‐hydroxytriptocalline A (=(2β,6α,8α,9β,10α,13α,14β,20β,22β)‐2,6,22‐trihydroxy‐9,13‐dimethyl‐24,25,26,30‐tetranorolean‐4‐ene‐3,21‐dione; 2 ), the new diterpenoid 11,16‐dihydroxy‐14‐methoxy‐18(4→3) abeo‐abieta‐3,8,11,13‐tetraene‐18‐oic acid named 16‐hydroxytriptobenzene H (=(4aS,10aS)‐3,4,4a,9,10,10a‐hexahydro‐5‐hydroxy‐7‐(2‐hydroxy‐1‐methylethyl)‐8‐methoxy‐1,4a‐dimethylphenanthrene‐2‐carboxylic acid; 3 ), and the abietane diterpenoid alkaloid named triptotin J (=(7aS,11aS,11bS)‐7,7a,8,9,10,11,11a,11b‐octahydro‐11b‐hydroxy‐α,α,8,8,11a‐pentamethyl‐6H‐naphth[1,2‐d]azepine‐4‐methanol; 4 ). Their structures were established on the basis of spectroscopic studies. |
