Synthesis of 4-aryl-2,3,6,7-tetrahydro-1H-pyrimido[4,5-b][1,4]-diazepin-6-ones from 4,5-diamino-1H-pyrimidin-6-ones and 1-aryl-3-(dimethylamino)-1-propanones |
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| Authors: | Braulio Insuasty,Jairo Quiroga,Juan Carlos Argoti,Samuel G mez,Roberto Martí nez,Enrique Angeles,Rub n Gabi o,Manuel Nogueras,Adolfo S nchez |
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| Affiliation: | Braulio Insuasty,Jairo Quiroga,Juan Carlos Argoti,Samuel Gómez,Roberto Martínez,Enrique Angeles,Rubén Gabiño,Manuel Nogueras,Adolfo Sánchez |
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| Abstract: | The reaction of 1-aryl-3-(dimethylamino)-1-propanones 1 with one equivalent of 4,5-diamino-1H-pyrimidin-6-ones 2 , in acidic medium, leads to the formation of 4-aryl-2,3,6,7-tetrahydro-1H-pyrimido[4,5-b]-[1,4]diazepin-6-ones 3 . The structure elucidation of the products is based on detail nmr analysis of experiments such as 13C, 1H and DEPT including selective 13C{1H} decoupling experiments. |
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