| 树脂法分离纯化米洛培南 |
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| 引用本文： | 杨秀云,印寿根,张政朴,郭红,张广明. 树脂法分离纯化米洛培南[J]. 离子交换与吸附, 2002, 18(2): 132-137 |
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| 作者姓名： | 杨秀云 印寿根 张政朴 郭红 张广明 |
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| 作者单位： | 南开大学高分子化学研究所,吸附分离功能高分子材料国家重点实验室,天津,300071;深圳太太药业集团研究所,深圳,518057 |
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| 摘 要： | 采用国产AAS大孔吸附树脂及D－280大孔脱色树脂对抗生素米洛培南制备母液进行分离纯化。实验表明,与日本Diaion公司生产的Diaion CHP20相比,AAS大孔吸附树脂对米洛培南具有更优良的吸附性能,使用D－280大孔脱色树脂对抗生素米洛培南制备母液进行脱色,未发现类似报道,分析结果证实,以上述方法制备的抗生素米洛培南收率高,纯度高,各项分析数据与文献报道相符。
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| 关 键 词： | AAS大孔吸附树脂 D-280大孔脱色树脂 米洛培南 分离 纯化 |
| 文章编号： | 1001-5493(2002)02-0132-06 |
| 修稿时间： | 2002-01-15 |
THE SEPARATION AND PURIFICATION OF MILUPEINAN BY ADSORPTION RESIN |
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| YAN Xiuyun YIN Shougeng ZHANG Zhengpu GUO Hong ZHANG Guangming State Key Lab. of Functional Polymeric Materials for Adsorption and Separation Institute of Polymer Chemistry,Nankai University,Tianjin ,P.R.China Institute of Taita Pha. THE SEPARATION AND PURIFICATION OF MILUPEINAN BY ADSORPTION RESIN[J]. Ion Exchange and Adsorption, 2002, 18(2): 132-137 |
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| Authors: | YAN Xiuyun YIN Shougeng ZHANG Zhengpu GUO Hong ZHANG Guangming State Key Lab. of Functional Polymeric Materials for Adsorption Separation Institute of Polymer Chemistry Nankai University Tianjin P.R.China Institute of Taita Pha |
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| Affiliation: | YAN Xiuyun1 YIN Shougeng1 ZHANG Zhengpu1 GUO Hong2 ZHANG Guangming2 1 State Key Lab. of Functional Polymeric Materials for Adsorption and Separation Institute of Polymer Chemistry,Nankai University,Tianjin 300071,P.R.China 2 Institute of Taita Pha |
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| Abstract: | Adsorption resin AAS has been used for the separation and purification of milupeinan (M-13) from its mother liquor. The good adsorption property of AAS adsorption resin was found for milupeinan (M-13) compared with the Diaion CHP 20p. When acetone and water (2:1 in volume) were used as desorption reagents, it was found that 3 times of bed volume of the desorption reagents could completely desorb the saturately adsorbed M-13 on AAS. Also macroporous strong basic anion exchange resin (Poly-4-vinylpyridine type) D-280 was used for the decolourization from M-13 solution. The good results were given when the sv=1~2 |
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| Keywords: | AAS adsorption resin D-280 decoloulization resin Milupeinan (M-13). |
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