| Convenient synthesis of （2S,3R,4R,5S,6R）-2-（3-（4-ethylbenzyl）-4- chlorophenyl）-6-（hydroxymethyl）-tetrahydro- 2H-pyran-3,4,5-triol |
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| 作者姓名： | Yong Hai Liu ;Da Li Li ;Lu De Lu ;Zhen Yuan Miao |
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| 作者单位： | a School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China;b School of Pharmacy, Second Military Medical University, Shanghai 200433, China |
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| 摘 要： | A convenient approach for the preparation of （2S,3R,4R,5S,6R）-2-（3-（4-ethylbenzyl）-4-chlorophenyl）-6-（hydroxymethyl）- tetrahydro-2H-pyran-3,4,5-triol I is developed. The target compound via four steps is synthesized from 4-bromo-2-（bromomethyl）- 1-chlorobenzene and the isomers of undesired ortho-products were avoided during the preparation.
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| 关 键 词： | 2型糖尿病 药物合成 钠 葡萄糖 抑制剂 |
Convenient synthesis of (2S,3R,4R,5S,6R)-2-(3-(4-ethylbenzyl)-4-chlorophenyl)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol |
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| Yong Hai Liu,;Da Li Li,;Lu De Lu,;Zhen Yuan Miao.Convenient synthesis of (2S,3R,4R,5S,6R)-2-(3-(4-ethylbenzyl)-4-chlorophenyl)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol[J].Chinese Chemical Letters,2008,19(7):814-816. |
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| Authors: | Yong Hai Liu Da Li Li Lu De Lu Zhen Yuan Miao |
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| Institution: | a School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China;b School of Pharmacy, Second Military Medical University, Shanghai 200433, China |
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| Abstract: | A convenient approach for the preparation of (2S,3R,4R,5S,6R)-2-(3-(4-ethylbenzyl)-4-chlorophenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 1 is developed.The target compound via four steps is synthesized from 4-bromo-2-(bromomethyl)-1-chlorobenzene and the isomers of undesired ortho-products were avoided during the preparation. |
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| Keywords: | Type 2 diabetes Sodium glucose co-transporter 2 Inhibitor Preparation |
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