A pH-response multifunctional nanoplatform based on NaGdF4:Yb,Er,Fe@Ce6@mSiO2-DOX for synergistic photodynamic/chemotherapy of cancer cells |
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| Institution: | 1. Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin 300070, China;2. Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin 300070, China;3. Department of Infection Management, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300202, China;4. Key Laboratory of Cancer Prevention and Therapy, Tianjin 300202, China;5. Tianjin''s Clinical Research Center for Cancer, Tianjin 300202, China;6. National Demonstration Center for Experimental Preventive Medicine Education (Tianjin Medical University), Tianjin 300070, China |
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| Abstract: | Cancer is one of the major diseases that seriously threaten human health. Drug delivery nanoplatforms for tumor treatment have attracted increasing attention owing to their unique advantages such as good specificity and few side effects. This study aimed to fabricate a pH-responsive drug release multifunctional nanoplatform NaGdF4:Yb,Er,Fe@Ce6@mSiO2-DOX. In the platform, Fe3+ doping enhanced the fluorescence intensity of NaGdF4:Yb, Er by 5.8 folds, and the mSiO2 shell substantially increased the specific surface area of nanomaterials (559.257 m2/g). The loading rates of chlorin e6 and doxorubicin hydrochloride (DOX) on NaGdF4:Yb,Er,Fe@Ce6@mSiO2-DOX reached 28.58 ± 0.85% and 87.53 ± 5.53%, respectively. Additionally, the DOX release rate from the nanoplatform was only 24.4% after 72 h at pH 7.4. However, under tumor microenvironment conditions (pH 5.0), the release rate of DOX increased to 85.3% after 72 h. The nanoplatform could generate reactive oxygen species (ROS) under 980 nm near-infrared excitation. Moreover, the nanoplatform exhibited a strong comprehensive killing efficiency against cancer cells. The viabilities of HeLa, MCF-7, and HepG2 cancer cells were only 18.5, 11.4, and 9.3%, respectively, after being treated with a combination of photodynamic therapy and chemotherapy. The constructed nanoplatform exhibits great application potential in cancer treatment. |
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| Keywords: | Nanoplatform Combined therapy Photodynamic therapy Cancer cells pH response FBS"} {"#name":"keyword" "$":{"id":"k0040"} "$$":[{"#name":"text" "_":"Fetal bovine serum FRET"} {"#name":"keyword" "$":{"id":"k0050"} "$$":[{"#name":"text" "_":"Fluorescence resonance energy transfer OA"} {"#name":"keyword" "$":{"id":"k0060"} "$$":[{"#name":"text" "_":"Oleic acid PBS"} {"#name":"keyword" "$":{"id":"k0070"} "$$":[{"#name":"text" "_":"Phosphate buffer saline PDT"} {"#name":"keyword" "$":{"id":"k0080"} "$$":[{"#name":"text" "_":"Photodynamic therapy ROS"} {"#name":"keyword" "$":{"id":"k0090"} "$$":[{"#name":"text" "_":"Reactive oxygen species TEM"} {"#name":"keyword" "$":{"id":"k0100"} "$$":[{"#name":"text" "_":"Transmission electron microscope |
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