| Yb/Er掺杂Y2O3纳米核壳颗粒的荧光性能及体内标定研究 |
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| 引用本文： | 麦金玲,王辰,徐梁格,黄宝玥,张力图.Yb/Er掺杂Y2O3纳米核壳颗粒的荧光性能及体内标定研究[J].中国无机分析化学,2022,12(5):80-85. |
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| 作者姓名： | 麦金玲 王辰 徐梁格 黄宝玥 张力图 |
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| 作者单位： | 广西医科大学 肿瘤医学院实验研究部,广西医科大学 肿瘤医学院实验研究部,哈尔滨工业大学 特种环境复合材料国防科技重点实验室,广西医科大学 肿瘤医学院实验研究部,广西医科大学 肿瘤医学院实验研究部 |
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| 基金项目： | 国家自然科学基金地区项目 (81760535); 广西重点研发计划 (桂科AB19110018); 南宁市青秀区科学研究与技术开发计划项目 (2017034; 2017036) |
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| 摘 要： | 为改善无机Y2O3上转换纳米粒子(UCNPs)的荧光性能,且同步实现其在生物体内的成像标定,通过共沉淀法及梯度合成工艺,制备出各组不同壳层厚度的Y2O3:Yb3+,Er3+@Y2O3:Yb3+ UCNPs。利用透射电子显微镜(TEM)扫描、X射线衍射(XRD)、上转换荧光(UCL)光谱、UCL寿命等对样品的形貌、结构及荧光性能进行了表征。结果表明：利用共沉淀法制得小尺寸Y2O3:Yb3+,Er3+@Y2O3:Yb3+纳米核壳颗粒,平均粒径范围在25.57~26.24 nm之间。通过调整Yb3+浓度和水浴时间优化合成工艺,获得高发射强度、长荧光寿命方案(80% Yb掺杂,8 h水浴)。高红绿比的荧光发射特征,决定其在小动物体内荧光标定检测时更宜采用红色信道。
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| 关 键 词： | 共沉淀法 Y2O3 核壳颗粒 荧光 |
| 收稿时间： | 2021/10/25 0:00:00 |
| 修稿时间： | 2021/10/29 0:00:00 |
Fluorescence properties and in vivo calibration of Yb/Er doped Y2O3 core-shell nanoparticles |
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| MAI Jinling,WANG Chen,XU Liangge,HUANG Baoyue and ZHANG Litu.Fluorescence properties and in vivo calibration of Yb/Er doped Y2O3 core-shell nanoparticles[J].Chinese Journal of Inorganic Analytical Chemistry,2022,12(5):80-85. |
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| Authors: | MAI Jinling WANG Chen XU Liangge HUANG Baoyue and ZHANG Litu |
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| Institution: | Research Department,Oncology Medical College,Guangxi Medical University,Nanning,Research Department,Oncology Medical College,Guangxi Medical University,Nanning,National Key Laboratory of Science and Technology on Advanced Composites in Special Environment,Harbin Institute of Technology,Harbin,Research Department,Oncology Medical College,Guangxi Medical University,Nanning,Research Department,Oncology Medical College,Guangxi Medical University,Nanning |
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| Abstract: | In order to improve the fluorescence properties of inorganic Y2O3 upconversion nanoparticles (UCNPs), and realize their in vivo imaging calibration simultaneously. Y2O3:Yb3+,Er3+@Y2O3:Yb3+ UCNPs with different shell thickness were prepared by co-precipitation and gradient synthesis. The morphology, structure and fluorescence properties of the samples were characterized by transmission electron microscopy (TEM) scanning, X-ray diffraction (XRD), up-conversion fluorescence (UCL) spectrum and UCL lifetime. The results show that the small size of Y2O3:Yb3+,Er3+@Y2O3:Yb3+ UCNPs core-shell particles were prepared by co-precipitation method, and the average particle size ranges from 25.57 nm to 26.24 nm. The synthesis process was optimized by adjusting the concentration of Yb3+ and water bath time, and the scheme of high emission intensity and long fluorescence life (80% Yb doping, 8 h water bath) was obtained. The fluorescence emission characteristics of high red-green ratio determine that red channel is more suitable for in vivo fluorescence calibration and detection in small animals. |
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| Keywords: | Co-precipitation method Y2O3 Core-shell particle Fluorescence |
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