Studies on Pyrazine Derivatives,XLII: Synthesis and Tuberculostatic Activity of 6-(1,4-Dioxa-8-azaspiro- [4, 5]-decano)- and 6-(1-Ethoxycarbonylpiperazino)- pyrazinocarboxylic Acid Derivatives |
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| Authors: | Barbara Milczarska Henryk Foks Zofia Zwolska |
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| Affiliation: | 1. Department of Organic Chemistry , Medical University of Gdańsk , Gdańsk , Poland;2. Department of Microbiology , Institute of Tuberculosis and Pulmonary Diseases , Warsaw , Poland |
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| Abstract: | ![]()
The 2-cyano-6-chloropyrazine's chlorine atom reactivity was substituted with amines 1,4-dioxo-8-azaspiro-[4, 5]-decane and 1-ethoxycarbonylpiperazine. The substrates thus obtained were used in the syntheses of the new derivatives, which were tested for their tuberculostatic activity. Minimum inhibitory concentration (MIC) value of the most active ones ( 5b , 12a , 14b , 16b , 21b ) was 25 μ g/mL. |
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| Keywords: | 2-Cyano-6-chloropyrazine 6-aminosubstituted-2-cyanopyrazine N1-substituted thioamidopyrazincarboxyamidrazones thioamides |
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