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Cufe2O4 Nanoparticles: A Magnetically Retrievable Catalyst for Green Synthesis of Novel 2-(3-(Dicyanomethyl)-2-Oxoindolin-3-Ylthio)Acetic Acids |
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| Authors: | Ghazaleh Imani Shakibaei Ramin Ghahremanzadeh Ayoob Bazgir |
| Institution: | 1. Department of Chemistry , Shahid Beheshti University , General Campus, Tehran , 1983963113 , Iran;2. Nanobiotechnology Research Center, Avicenna Research Institute, Academic Center for Education, Culture and Research (ACECR) , Tehran , Iran |
| Abstract: | Abstract A highly efficient and green method for the synthesis of new 2-(3-(dicyanomethyl)-2-oxoindolin-3-ylthio)acetic acids is described using magnetically recoverable and reusable CuFe2O4 nanoparticles. A wide variety of aryl isatylidene malononitrils underwent Micheal addition with thioacids to afford novel 2-(3-(dicyanomethyl)-2-oxoindolin-3-ylthio)acetic acids in good to excellent yields. The reaction protocol is operationally simple and mild. Moreover, water as solvent makes the reaction procedure eco-friendly and economically viable. All products were characterized by NMR and IR spectroscopies. |
| Keywords: | Michael addition oxindole green chemistry copper ferrite nanoparticles magnetic separation |