A Facile Synthesis of 3H-Benzo[1,2]Dithiole-3-Thiones and Their Condensation with Active Methylene Compounds |
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| Authors: | Hongwei Jin Dong Jiang Jianrong Gao Genrong Qiang Yuan Gong |
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| Institution: | College of Chemical Engineering and Materials Science , Zhejiang University of Technology , Hangzhou, 310014, China |
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| Abstract: | Abstract 3H-Benzo1,2]-dithiole-3-thiones were prepared from potassium sulfide and 2-halobenzaldehydes in moderate-to-good yields, and a plausible mechanism for this catalyst-free intramolecular heteroannulation reaction has been proposed. The Knoevenagel condensation reactions of 3H-benzo1,2]dithiole-3-thiones with active methylene compounds such as ethyl 2-cyanoacetate and diethyl malonate, and the three-component one-pot reactions of potassium sulfide, 2-halobenzaldehydes, and ethyl 2-cyanoacetate, affording the corresponding products, have been developed. GRAPHICAL ABSTRACT  |
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| Keywords: | 3H-Benzo[1 2]dithiole-3-thiones potassium sulfide 2-halobenzaldehydes Knoevenagel condensation one-pot reaction three-component reaction |
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