Synthesis and Bioassay of Ethyl-2- (2-((Diethoxyphosphoryl) (Aryl) Methylamino)Thiazol-4-Yl)-2-(Methoxyimino)Acetates |
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| Authors: | S Santhi Sudha Ch Syama Sundar N Bakthavatchala Reddy K Uma Maheswara Rao S H Jaya Prakash C Suresh Reddy |
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| Institution: | 1. Department of Chemistry, Sri Venkateswara University College of Science , Sri Venkateswara University , Tirupati , 517502 , India;2. Department of Chemistry , Yonsei University , Gangwon-do , 220-710 , South Korea |
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| Abstract: | Abstract A simple, efficient, and environmentally benign methodology has been accomplished for the synthesis of α-aminophosphonates by one-pot three-component reaction of ethyl-2-amino-α-(methoxy-imino)-4-thiazoleacetate, aldehydes, and diethylphosphite by using Amberlyst-15 as catalyst at room temperature under solvent-free conditions. Their chemical structures were characterized by infrared (IR), NMR (1H, 13C & 31P), mass spectral, and elemental analysis. All the title compounds were screened for radical-scavenging activity by 1,1-diphenyl-2-picrylhydrazyl (DPPH), nitic oxide (NO), and hydrogen peroxide (H2O2) methods. Supplementary materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements for the following free supplemental files: Additional text and figures. |
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| Keywords: | α-Aminophosphonates Amberlyst-15 biological activity ethyl-2-amino-α-(methoxy-imino)-4-thiazoleacetate |
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