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PHOSPHORUS-CONTAINING AMINOCARBOXYLIC ACIDS. COMMUNICATION IV.1 A CONVENIENT METHOD OF PHOSPHONIC ACIDS SYNTHESIS |
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| Authors: | V V Ragulin M E Bofanova Eugene N Tsvetkov |
| Institution: | Institute of Physiologically Active Substances, USSR Academy of Sciences , 142432 Chernogolovka, Moscow Region, USSR |
| Abstract: | Abstract The communication is concerned with the synthesis of phosphonic aminocarboxylic acids by phosphorylation of diethyl ω-halogen alkyl acetamidomalonates with tris(trimethylsilyl) phosphite, followed by alcoholysis and acid hydrolysis of the resulting intermediate esters. |
| Keywords: | Phosphonic aminocarboxylic acids tris(trimethylsilyl) phosphite ω-halogenalkyl acetamidomalonates phosphorylation alcoholysis hydrolysis |