Studies on 2-Aminothiophenes: Synthesis,Transformations, and Biological Evaluation of Functionally-Substituted Thiophenes and Their Fused Derivatives |
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| Authors: | Wagnat W Wardakhan Hatem M Gaber Salama A Ouf Sherif M Sherif |
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| Institution: | 1. National Organization for DrugControl and Research (NODCAR) , Cairo, Egypt;2. Department of Botany , Faculty of Science, Cairo University , Giza, Egypt;3. Department of Chemistry , Faculty of Science, Cairo University , Giza, Egypt |
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| Abstract: | Abstract Heterocyclic enamines1 reacted with ethyl acetoacetate to afford the corresponding amide derivatives2. Treatment of2 with carbon disulphide yielded the dipotassium salts3which reacted in-situ with a variety of α -haloketones to give the respective substituted thiophenes5,8, and13. The reactivity of the latter products towards various chemical reagents was studied to yield their fused thiophene derivatives7,10,12, and14, respectively. Some representative compounds were tested for antimicrobial activity. |
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| Keywords: | 2-Aminothiophenes α-haloketons antimicrobial activities enamines fused thiophenes |
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