Multicomponent one-pot synthesis of (dihydro-1H-benzo[d]imidazole) phosphonate |
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| Authors: | José Luis Castrejon-Flores Oscar Ernesto Guevara-Moreno Raúl Ricardo Díaz-Contreras Atilano Gutiérrez-Carrillo Marco Franco-Pérez |
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| Institution: | 1. Unidad Profesional Interdisciplinaria de Biotecnología, Instituto Politécnico Nacional, Ciudad de México, México;2. Departamento de Química, División de Ciencias Básicas e Ingeniería, Universidad Autónoma Metropolitana-Iztapalapa, Ciudad de México, México;3. Departamento de Física y Química Teórica, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, México |
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| Abstract: | AbstractWe present a multicomponent reaction strategy to synthesize a (dihydro-1H-benzod]imidazole)phosphonate family of compounds, using benzimidazoles, diethyl chlorophosphate and aliphatic amines as starting reactants. Giving its simplicity, our procedure involves reaction times of only few hours and avoid the usage of any catalyst agent. All the newly synthesized compounds were characterized by Nuclear Magnetic Resonance spectroscopy (1H, 13C and 31P) and mass spectrometry by the DART method. |
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| Keywords: | Multicomponent reactions benzimidazoles diethyl chlorophosphate |
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