Design and Enantioselective Synthesis of Phosphonates as Enzyme Inhibitors |
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| Authors: | Carol Bergin Robert Hamilton Eanna O'maitiu Brian Walker Brian J. Walker |
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| Affiliation: | 1. School of Chemistry , Belfast, BT9 5AG;2. School of Biology and Biochemistry, David Keir Building, The Queen's University of Belfast , Belfast, BT9 5AG |
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| Abstract: | Abstract The serine proteases [1] form an important group of hydrolytic enzymes essential to a variety of biological activities ranging from food digestion to blood clotting. However their uncontrolled activity is also known to be implicated in a number of pathological conditions including emphysema, cystic fibrosis, cancer and myocardial infarction. Their selective control is therefore an important goal and could offer a basis for the rational design of therapeutic agents. |
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