Polymorphs of nitrofurantoin. I. Preparation and X-ray crystal structures of two monohydrated forms of nitrofurantoin期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Polymorphs of nitrofurantoin. I. Preparation and X-ray crystal structures of two monohydrated forms of nitrofurantoin

Authors:	E. W. Pienaar M. R. Caira A. P. Lötter

Affiliation:	(1) Research Institute for Industrial Pharmacy, Potchefstroom University for C.H.E., 2520 Potchefstroom, South Africa;(2) Department of Chemistry, University of Cape Town, Private Bag, 7700 Rondebosch, South Africa

Abstract:	The preparation and X-ray crystal structures of two monohydrates of the antibacterial drug nitro furantoin are reported. MonohydrateI crystallizes in the monoclinic space groupP2₁n and monohydrateII in the orthorhombic space group Pbca. The nitrofurantoin molecule maintains the same, planar conformation in both crystals. The molecular packing arrangements inI andII are distinctly different,I possessing a layer structure while inII the packing is based on a herring bone motif. Hydrogen bonds of the type O-HO, N-HO, O-HN and C-HO stabilize the crystal structures.

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