Macromolecular crystallography research at Trombay |
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Authors: | K K Kannan and R Chidambaram |
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Institution: | (1) Neutron Physics Division, Bhabha Atomic Research Centre, 400 085 Bombay, India |
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Abstract: | Neutron diffraction studies of hydrogen positions in small molecules of biological interest at Trombay have provided valuable
information that has been used in protein and enzyme structure model-building and in developing hydrogen bond potential functions.
The new R-5 reactor is expected to provide higher neutron fluxes and also make possible smallangle neutron scattering studies
of large biomolecules and bio-aggregates. In the last few years infrastructure facilities have also been established for macromolecular
x-ray crystallography research. Meanwhile, the refinement of carbonic hydrases’ and lysozyme structures have been carried
out and interesting results obtained on protein dynamics and structure-function relationships. Some interesting presynaptic
toxin phospholipases have also been taken up for study. |
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Keywords: | Protein crystallography enzyme mechanism neutron diffraction x-ray diffraction carbonic anhydrase lysozyme presynaptic toxins |
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