Highly-loaded amphiphilic polyimino resin: quench reagent and solid support for peptide synthesis |
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| Authors: | Houcine Rahali |
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| Affiliation: | a CNRS, UMR Ecofog, Institut d’Enseignement Supérieur de la Guyane, BP 792, 97337 Cayenne cedex, France
b LAPP (UMR 5810), Université de Montpellier 2, 34390 Montpellier cedex 5, France |
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| Abstract: | We demonstrate herein that polyimino resin 4a prepared by condensation of α,α′-dichloro-p-xylene, ethylenediamine and tris-(2-aminoethyl)-amine can be successfully exploited as a quench reagent for acids and electrophiles both in aqueous and organic solutions. Scope and limitations of such a resin as a solid support for peptide synthesis were also investigated. |
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