| 结石患者和健康对照者尿微晶生长、聚集过程的比较研究 |
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| 引用本文： | 柳一鸣,夏志月,欧阳健明,贾丽萍,张广娜,丁一鸣.结石患者和健康对照者尿微晶生长、聚集过程的比较研究[J].无机化学学报,2013,29(5):903-909. |
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| 作者姓名： | 柳一鸣 夏志月 欧阳健明 贾丽萍 张广娜 丁一鸣 |
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| 作者单位： | 1. 湖南理工学院化学化工学院,岳阳4140001 ;暨南大学生物矿化与结石病防治研究所,广州 510632
2. 暨南大学生物矿化与结石病防治研究所,广州,510632 |
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| 基金项目： | 国家自然科学基金(NO.81170649)和湖南省自然科学基金(No.S2012J5042)和湖南省教育厅科研项目(No.12C0702)资助项目。 |
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| 摘 要： | 采用扫描电子显微镜(SEM)和X-射线粉末衍射仪(XRD)比较研究了5例泌尿系结石患者和5名健康对照者的尿微晶的生长动力学差异。随着生长时间(t)增加,结石患者尿微晶尺寸不断增大,粒径从t=1 h时的约(6±4)μm增加到t=48 h的(29±17)μm,但微晶数密度从(1 400±300)mm-2逐渐减少至(450±140)mm-2,表明在患者尿液中微晶的形成过程为生长控制;相比之下,在对照者尿液中,随着t从1 h增加48 h,尿微晶数密度从(850±260)mm-2减少至(610±210)mm-2,微晶尺寸从(6±5)μm增加至(15±9)μm,这表明其生长过程同时为成核控制和生长控制。上述差异归因于对照者尿液中抑制剂的浓度和活性均比结石患者的高,更能抑制尿微晶的生长和聚集。
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| 关 键 词： | 尿微晶 动力学 SEM XRD 肾结石 |
| 收稿时间： | 8/7/2012 12:00:00 AM |
| 修稿时间： | 2012/11/8 0:00:00 |
Comparative Study of Growth and Aggregation Process of Urinary Crystallites in Urines of Stone Patients and Healthy Controls |
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| LIU Yi-Ming,XIA Zhi-Yue,OUANG Jian-Ming,JIA Li-Ping,ZHANG Guang-Na and DING Yi-Ming.Comparative Study of Growth and Aggregation Process of Urinary Crystallites in Urines of Stone Patients and Healthy Controls[J].Chinese Journal of Inorganic Chemistry,2013,29(5):903-909. |
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| Authors: | LIU Yi-Ming XIA Zhi-Yue OUANG Jian-Ming JIA Li-Ping ZHANG Guang-Na and DING Yi-Ming |
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| Institution: | Department of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Yueyang, Hunan 414000, China;Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou 510632, China;Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou 510632, China;Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou 510632, China;Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou 510632, China;Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou 510632, China;Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou 510632, China |
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| Abstract: | |
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| Keywords: | urinary crystallites kinetics SEM XRD renal stones |
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