Sulfur-containing 2-arylquinolinemethanols as potential antimalarials

The synthesis and antimalarial activity of six new 2-arylquinoline-4-methanols is described. The compounds bearing a sulfur were prepared to determine if antimalarial activity can be retained while photo-reactivity and phototoxicity is diminished by such substituents. The observed antimalarial activity of some of the new compounds show this to be possible.