Retention of analgin and anesthesin on sorbents with different polarities: The analysis of bellalgin tablets by high-performance liquid chromatography |
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| Authors: | G. B. Golubitskii E. V. Budko E. M. Basova A. V. Kostarnoi V. M. Ivanov |
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| Affiliation: | (1) OAO Farmstandart-Leksredstva, Vtoraya Agregatnaya ul. 1a/18, Kursk, 305039, Russia;(2) Kursk State Medical University, ul. K. Marksa 3, Kursk, 305004, Russia;(3) Dubna International University of Nature, Society, and Human Being, ul. Universitetskaya 19, Dubna, Moscow oblast, 141980, Russia;(4) Department of Chemistry, Moscow State University, Vorob’evy gory, Moscow, 119992, Russia |
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| Abstract: | The effects of acetonitrile and potassium dihydrogen phosphate concentrations in a mobile phase and the pH of the mobile phase on the retention of analgin (dipyrone) and anesthesin (benzocaine) on Symmetry C18 and Nova-Pak CN HP sorbents with grafted octadecylsilanol and nitrile groups, respectively, were studied. It was found that, under identical conditions, retention on the sorbent with grafted nitrile groups was weaker. A rapid and cost-effective procedure was developed for the determination of analgin and anesthesin in the analysis of Bellalgin tablets. |
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