过渡金属催化的1,n-烯炔类化合物的不对称环异构化反应

过渡金属催化的不对称环异构化反应催化活性高、选择性好,被认为是一条符合原子经济性的合成途径。近年来,该领域取得了长足的进步,成为构建高官能团活性的手性碳环与杂环化合物的最有效手段之一。本文综述了20年来过渡金属催化的1,n-烯炔类化合物的不对称环异构化反应,并简要介绍了该反应在天然产物合成过程中的应用。

Asymmetric Cycloisomerization of 1,n-Enynes Catalyzed by Transition Metals

Asymmetric cycloisomerization catalyzed by transition metals, which possesses highly catalytic activity and good selectivity, is a potential protocol to fulfill the goal of “atom economic”.In recent years, impressive achievements have been made in this area. It becomes one of the most efficient methods to synthesize enantiomeric pure carbon- or heterocyclic compounds. This paper summarized the development of transition metal catalyzed asymmetric cycloisomerization in recent twenty years and briefly reviewed its applications in total synthesis of natural products.Contents 
1 Introduction 
2 Asymmetric cycloisomerization of enynes catalyzed by different transition metals 
2.1 Palladium-catalyzed reactions 
2.2 Rhodium-catalyzed reactions 
2.3 Platinum, gold and iridium-catalyzed reactions 
3 Applications in the syntheses of natural products
3.1 Asymmetric transformation catalyzed by chiral catalysts 
3.2 Asymmetric transformation induced by chiral substrates 
4 Conclusion