Titanocene(III)-promoted Barbier-type crotylation of carbonyl compounds |
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| Authors: | Sancho-Sanz Iris Miguel Delia Millán Alba Estévez Rosa E Oller-López Juan L Álvarez-Manzaneda Enrique Robles Rafael Cuerva Juan M Justicia José |
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| Affiliation: | Department of Organic Chemistry, Faculty of Sciences, University of Granada, C. U. Fuentenueva s/n, 18071 Granada, Spain. |
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| Abstract: | ![]()
A mild, highly regio- and stereoselective method for the crotylation of aldehydes and ketones mediated/catalyzed by titanocene(III) is described. Optimized conditions permit the selective generation of γ-adducts in high yields together with high stereoselectivity, with a predominance of anti stereoisomers. |
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