Incorporation of biotinylated manganese-salen complexes into streptavidin: New artificial metalloenzymes for enantioselective sulfoxidation |
| |
| Authors: | A. Pordea T.R. Ward |
| |
| Affiliation: | a Institute of Chemistry, University of Neuchâtel, Avenue Bellevaux 51, CP 158, CH-2009 Neuchâtel, Switzerland
b Department of Chemistry, University of Basel, Spitalstrasse 51, CH-4056 Basel, Switzerland |
| |
| Abstract: | Incorporation of achiral biotinylated manganese-salen complexes into streptavidin yields artificial metalloenzymes for aqueous sulfoxidation using hydrogen peroxide. Four biotinylated salen ligands were synthesized and their manganese complexes were tested in combination with several streptavidin mutants, yielding moderate conversions (up to 56%) and low enantioselectivities (maximum of 13% ee) for the sulfoxidation of thioanisole. |
| |
| Keywords: | Enantioselective catalysis Artificial metalloenzyme Biotin-avidin technology Oxidation Schiff base |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
