| A practical stereoselective synthesis of (S)-( - )-ofloxacin |
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| 作者姓名： | 杨玉社 嵇汝运 陈凯先 |
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| 作者单位： | YANG，Yu-She JI，Ru-Yun CHEN，Kai-Xian
Shanghai Institute of Materia Medica，Chinese Academy of Sciences，Shanghai 200031，China |
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| 基金项目： | National Natural Science Foundtion of China. |
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| 摘 要： | A very efficient and practical procedure for preparation of ( S)-( - )-ofloxacin has been developed (10 steps, overall yield ≥ 45 % ) . The key step of this approach is the regioselective nucleophilic substitution of 2-position fluorine atom of 2,3,4-tirfluoronitrobenzene by (S)-glycerol acetonide.
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A practical stereoselective synthesis of (S)-( - )-ofloxacin |
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| YANG,Yu-She JI,Ru-Yun CHEN,Kai-Xian.A practical stereoselective synthesis of (S)-( - )-ofloxacin[J].Chinese Journal of Chemistry,1999,17(5):539-544. |
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| Authors: | YANG Yu-She JI Ru-Yun CHEN Kai-Xian |
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| Institution: | YANG,Yu-She JI,Ru-Yun CHEN,Kai-Xian
Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 200031,China |
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| Abstract: | A very efficient and practical procedure for preparation of ( S)-( - )-ofloxacin has been developed (10 steps, overall yield ?45%). The key step of this approach is the regioselective nucleophilic substitution of 2-position fluorine atom of 2,3,4 tirfluoronitrobenzene by (S)-glycerol acetonide. |
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| Keywords: | (S)-( - )-Ofloxacin stereoselective synthesis quinolone antibacterial agent |
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