Solid-Phase Synthesis of a Monofunctional trans-a(2)Pt(II) Complex Tethered to a Single-Stranded Oligonucleotide |
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| Authors: | Schmidt Filippov Meeuwenoord van Der Marel GA van Boom JH Lippert Reedijk |
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| Institution: | Leiden Institute of Chemistry Gorlaeus Laboratories, Leiden University 2300 RA Leiden (The Netherlands). |
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| Abstract: | Cross-linking ability is possible with the oligonucleotide-tethered, monofunctional trans-Pt(II) complex shown. It was synthesized by a novel solid-phase approach comprising conjugation of immobilized tetrathymidylic acid with a trans-a(2)Pt(II) building unit, ammonolysis, and transformation of the resulting complex (R=1-N-cyclohexylmethylthyminate) into the chloro derivative (R=Cl). a=NH(2)CH(3), T=thymine. |
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