Optimization of the Production Medium for Biosynthesis of Antifungal Antibiotic Ak-111-81 by Phosphate-Deregulated Mutant of <Emphasis Type="Italic">Streptomyces hygroscopicus</Emphasis> |
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Authors: | Victoria Gesheva |
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Institution: | (1) Institute of Microbiolgy, Bulgarian Academy of Sciences, Department of Microbial Biosynthesis and Biotechnology, Sofia, 1113, Bulgaria |
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Abstract: | Experimental mathematical designs were applied for optimization of a nutrient medium for biosynthesis of the antifungal antibiotic
AK-111-81 by phosphate-deregulated mutant of Streptomyces hygroscopicus 111-81. Antifungal antibiotic AK-111-81 possesses well-expressed activity against Fusarium graminearum and other phytopathogenic fungi. The level of the production of the antibiotic AK-111-81 on this medium is more than three
times higher than on the initial medium. The optimized quantitative composition of the nutrient culture media is (g/l): glucose,
20; soy meal, 18; ammonium succinate, 3; CaCO3, 1. |
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Keywords: | Streptomyces hygroscopicus Phosphate-deregulated mutant Optimal production medium Optimization Antifungal antibiotic AK-111-81 |
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