| Synthesis of Novel Nucleoside Analog （3R）-2,3-Dideoxy-3-（N-hydroxy-N-methylamino）-L-arabinofuranosyl Uracil |
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| 作者姓名： | JiChengCHU HongShengGUO JunBiaoCHANG KangZHAO |
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| 作者单位： | CollegeofPharmaceuticalsandBiotechnology,TianjinUniversity,Tianj~n300072 |
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| 摘 要： | The synthesis of novel nucleoside analog (3R)-2,3-dideoxy-3-(N-hydroxy-N-methylamino)-L-arabinofuranosyl uracil was studied. A twelve-step synthetic route, started from L-ascorbic acid, was designed, and the final product was obtained in 20.8% yield.
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| 关 键 词： | 合成 核苷类似物 （3R）-2 3-二脱氧-3-（N-羟基-N-甲基氨基）-L-阿糖呋喃尿嘧啶 Wittig反应 |
Synthesis of Novel Nucleoside Analog (3R)-2,3-Dideoxy-3- (N-hydroxy-N-methylamino)-L-arabinofuranosyl Uracil |
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| JiChengCHU HongShengGUO JunBiaoCHANG KangZHAO.Synthesis of Novel Nucleoside Analog (3R)-2,3-Dideoxy-3- (N-hydroxy-N-methylamino)-L-arabinofuranosyl Uracil[J].Chinese Chemical Letters,2004,15(7):785-786. |
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| Authors: | Ji Cheng CHU Hong Sheng GUO Jun Biao CHANG Kang ZHAO College of Pharmaceuticals and Biotechnology Tianjin University Tianjin |
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| Institution: | Ji Cheng CHU,Hong Sheng GUO,Jun Biao CHANG,Kang ZHAO College of Pharmaceuticals and Biotechnology,Tianjin University,Tianjin 300072 |
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| Abstract: | The synthesis of novel nucleoside analog (3R)-2,3-dideoxy-3-(N-hydroxy-N- methylamino)-L-arabinofuranosyl uracil was studied. A twelve-step synthetic route, started from L-ascorbic acid, was designed, and the final product was obtained in 20.8% yield. |
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| Keywords: | L-Nucleoside Wittig reaction Michael addition uracil analog |
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