Synthesis of a TMC-95A ketomethylene analogue by cyclization via intramolecular Suzuki coupling |
| |
| Authors: | Kaiser Markus Siciliano Carlo Assfalg-Machleidt Irmgard Groll Michael Milbradt Alexander G Moroder Luis |
| |
| Affiliation: | Max-Planck-Institut für Biochemie, AG Bioorganische Chemie, 82152 Martinsried, Germany. |
| |
| Abstract: | ![]()
[structure: see text] A TMC-95A analogue extended at the C-terminus with NlePsi[COCH(2)]Gly-Ala-Ala-NH(2) was synthesized via side-chain cyclization of the linear precursor by a Suzuki cross-coupling reaction in solution to analyze the effect of additional P' residues on the inhibitory potency against yeast proteasome. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
