| 新型含二硫键的环肽的合成 |
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| 引用本文： | 黄小毅,王涛,夏传琴,余孝其,谢如刚. 新型含二硫键的环肽的合成[J]. 有机化学, 2004, 24(12): 1629-1632 |
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| 作者姓名： | 黄小毅 王涛 夏传琴 余孝其 谢如刚 |
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| 作者单位： | 四川大学化学学院,成都,610064 |
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| 摘 要： | 本实验设计从Boc-Glu-OH,Boc-Asp-OH的两个羧基出发,最后通过I2氧化两个半胱氨酸的巯基生成二硫键,得到一类新型含二硫键的环肽,该环肽通过1H NMR,MS等确定了其结构.
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| 关 键 词： | 环肽 二硫键 合成 |
| 修稿时间： | 2004-03-22 |
Synthesis of Novel Disulfide Bond-Bearing Cyclopeptides |
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| HUANG,Xiao-Yi WANG,Tao XIA,Chuan-Qin YU,Xiao-Qi XIE,Ru-Gang. Synthesis of Novel Disulfide Bond-Bearing Cyclopeptides[J]. Chinese Journal of Organic Chemistry, 2004, 24(12): 1629-1632 |
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| Authors: | HUANG Xiao-Yi WANG Tao XIA Chuan-Qin YU Xiao-Qi XIE Ru-Gang |
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| Abstract: | Novel disulfide bond-bearing cyclopeptides have been designed and synthesized by iodine oxidation of bis (S-Acm) of Boc-Glu-(Leu-Cys-OMe)-Leu-Cys-OMe and Boc-Asp-(Leu-Cys-OMe)-Leu-Cys-OMe in high dilute condition. The reaction products were identified by 1H NMR and MS spectra. |
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| Keywords: | cyclopeptide disulfide bond synthesis |
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