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Distorted Phthalocyanines by Click Chemistry: Photoacoustic,Photothermal, and Surface-Enhanced Resonance Raman Studies |
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| Authors: | Dr. Waqar Rizvi Naxhije Berisha Dr. Christopher Farley Dr. N. V. S. Dinesh K. Bhupathiraju Dr. Chrysafis Andreou Emaad Khwaja German V. Fuentes Dr. Moritz F. Kircher Dr. Ruomei Gao Dr. Charles Michael Drain |
| Affiliation: | 1. Department of Chemistry, Hunter College of the City University of New York, New York, New York, 10065 USA;2. Department of Radiology, Memorial Sloan Kettering Cancer Center New York, New York, 10065 USA;3. Institute for Cancer Research and Education, SUNY Old Westbury, Old Westbury, New York, 11568 USA |
| Abstract: | Distortion of nominally planar phthalocyanine macrocycles affects the excited state dynamics in that most of the excited-state energy decays through internal conversion. A click-type annulation reaction on a perfluorophthalocyanine platform appending a seven-membered ring to the β-positions on one or more of the isoindoles distorts the macrocycle and modulates solubility. The distorted derivative enables photoacoustic imaging, photothermal effects, and strong surface-enhanced resonance Raman signals. |
| Keywords: | click chemistry photoacoustic imaging photothermal therapy phthalocyanines Raman spectroscopy |