CoI-Catalyzed Barbier Reactions of Aromatic Halides with Aromatic Aldehydes and Imines |
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| Authors: | Dr Marc Presset Dr Jérôme Paul Ghania Nait Cherif Nisanthan Ratnam Nicolas Laloi Prof Eric Léonel Dr Corinne Gosmini Prof Erwan Le?Gall |
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| Institution: | 1. Électrochimie et Synthèse Organique, Université Paris Est, ICMPE (UMR 7182), CNRS, UPEC, 2-8 rue Henri Dunant, F-94320 Thiais, France;2. LCM, CNRS, Ecole polytechnique, Institut Polytechnique de Paris, 91128 Palaiseau Cedex, France |
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| Abstract: | The reductive Barbier coupling of aromatic halides and electrophiles has been achieved using a CoBr2/1,10-phenanthroline catalytic system and over stoichiometric amounts of zinc. The reaction displayed a broad scope of substrates, including (hetero)aryl chlorides as pro-nucleophiles and aldehydes or imines as electrophiles, leading to diarylmethanols and diarylmethylamines in moderate to excellent yields, respectively. |
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| Keywords: | Barbier cobalt Mannich reductive coupling zinc |
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