|
|||||
|
|
Glycopeptides by Linch-Pin C?H Activations for Peptide-Carbohydrate Conjugation by Manganese(I)-Catalysis |
|
| Authors: | Wei Wang Dr Parthasarathi Subramanian Oscar Martinazzoli Jun Wu Prof?Dr Lutz Ackermann |
| Institution: | 1. Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstrasse 2, 37077 Göttingen, Germany;2. Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstrasse 2, 37077 Göttingen, Germany
These authors contributed equally to this work. |
| Abstract: | Late-stage C?H glycosylations of structurally complex amino acids and peptides were accomplished by means of racemization-free manganese(I)-catalyzed C?H activation. Thus, glycosylative modifications proved to be viable by a linch-pin approach, featuring chemo- and site-selective C?H transformations. The peptide–saccharide conjugation provided modular access to structurally complex glycopeptides, likewise enabling the assembly of fluorescent-labelled glycopeptides. |
| Keywords: | C?H activation glycoconjugation glycopeptides manganese natural products |