Catalytic Alkynylation of Polyfluoroarenes by Amide Base Generated In Situ |
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| Authors: | Dr. Masanori Shigeno Takuya Okawa Masaya Imamatsu Kanako Nozawa-Kumada Yoshinori Kondo |
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| Affiliation: | Department of Biophysical Chemistry, Graduate School of Pharmaceutical Sciences., Tohoku University, Aoba, Sendai, 980-8578 Japan |
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| Abstract: | We herein demonstrate that the amide base generated in situ from CsF and N(TMS)3 catalyzes the deprotonative coupling reactions of terminal alkynes with polyfluoroarenes, wherein mono- and dialkynylations occur efficiently for penta- and hexafluorobenzenes, respectively. Tetraalkynylated products could also be synthesized from dialkynylated compounds. |
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| Keywords: | alkynes amide base aromatic substitution C−C coupling polyfluoroarenes |
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