Simultaneous reduction of nitro- to amino-group in the palladium-catalyzed Suzuki cross-coupling reaction |
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| Authors: | Heng-Shan Wang Ying-Chun Wang Ying-Ming Pan Zhen-Feng Chen |
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| Affiliation: | a Key Laboratory of Medicinal Chemical Resources and Molecular Engineering, College of Chemistry and Chemical Engineering, Guangxi Normal University, Guilin 541004, China
b College of Chemistry and Chemical Engineering, Jishou University, Jishou 416000, PR China |
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| Abstract: | An efficient method for palladium-catalyzed Suzuki cross-coupling reaction with simultaneous reduction of nitro- to amino-group has been developed. This method allows nitro-substituted aryl halides to readily react with arylboronic acids, to afford aryl substituted aniline in low to excellent yields. The reaction was catalyzed by Pd(OAc)2 (3 mol %) at 150 °C under atmospheric pressure in the presence of K2CO3 (3 equiv) in DMF/H2O (5/1). |
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| Keywords: | Palladium Suzuki cross-coupling Reduction Aryl substituted aniline |
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