The catalytic asymmetric addition of alkyl- and aryl-zinc reagents to an isoxazole aldehyde |
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| Authors: | Jared K Nelson Trinidad J Villalobos |
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| Institution: | a Department of Chemistry, University of Idaho, Moscow, ID 83844-2343, USA
b COBRE Center for Structural and Functional Neuroscience, The University of Montana, Missoula, MT 59812, USA |
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| Abstract: | Nucleophilic addition of alkyl- and aryl-zinc reagents to a C(4) functionalized isoxazolyl aldehyde proceeded effectively with high enantioselectivity (85-94% ee). The amino alcohol catalyst (S)-2-piperidinyl-1,1,2-triphenyl ethanol (10) afforded the (R)-product 2b, as established by X-ray crystallography. |
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