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A novel and facile synthesis of 2-(cyclohexylamino)-6,7-dihydro-3-aryl-1H-indole-4(5H)-ones via a one-pot multi-component reaction
Authors:Majid M. Heravi  Bita Baghernejad  Hossein A. Oskooie  Rahim. Hekmatshoar
Affiliation:Department of Chemistry, School of Science, Azzahra University, Vanak, Tehran, Iran
Abstract:A simple and efficient synthesis of 2-(cyclohexylamino)-6,7-dihydro-3-aryl-1H-indole-4(5H)-ones was achieved via a one-pot multi-component reaction of cyclohexyl isocyanide, an aldehyde, a 1,3-dicarbonyl compound, and ammonium acetate in the presence of a catalytic amount of KHSO4 in acetonitrile.
Keywords:Cyclohexyl isocyanide   1,3-Dicarbonyl compound   Multi-component reaction   1H-Indole-4(5H)-ones
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