a Laboratoire de Transformations Chimiques et Pharmaceutiques, UMR CNRS 7084, Conservatoire National des arts et métiers, Case 303, 2 rue Conté, 75003 Paris, France b Guerbet, Centre de Recherche, BP 57400, 95943 Roissy CdG Cedex, France
Abstract:
A novel amphiphilic contrast agent, a GdPCTA-12] derivative containing a dodecyl chain as lipophilic moiety, has been prepared. A convergent synthetic route from commercially available diethylene triamine and 3-hydroxypyridine is described. The target amphiphilic gadolinium complex was obtained in nine steps in 22% overall yield. Physicochemical properties and relaxivity measurements of this new contrast agent are described.