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Highly regioselective palladium-catalyzed methoxycarbonylation of styrene using chiral ferrocene- and biphosphole-based ligands |
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| Authors: | Lisa Diab Maryse Gouygou Eric Manoury Philippe Kalck |
| Institution: | a Laboratoire de chimie de coordination du CNRS, UPR 8241, 205 route de Narbonne, 31400 Toulouse cedex 4, France b Laboratoire de chimie de coordination du CNRS, UPR 8241 Composante ENSIACET-INP, 118 route de Narbonne, 31077 Toulouse cedex 4, France |
| Abstract: | The methoxycarbonylation of styrene has been studied using Pd(OAc)2/L/acid catalytic systems with L being chiral ferrocene- and biphosphole-based ligands. Good activities are obtained in mild conditions. Chemoselectivities and regioselectivities (up to 98% in favour of the branched isomer) are excellent but enantioselectivities remain moderate (ee up to 17%). |
| Keywords: | Methoxycarbonylation Palladium P S ligands P P ligands Regioselectivity Enantioselectivity Vinylarenes |
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