Facile preparation of thiophene C2-ethers using the Mitsunobu reaction |
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| Authors: | Craig S. Harris,Hervé Germain,Georges Pasquet |
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| Affiliation: | AstraZeneca, Centre de Recherches, Z.I. la Pompelle, BP1050, 51689 Reims Cedex 2, France |
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| Abstract: | ![]()
The preparation of thiophene ethers generally requires forcing conditions thus limiting the choice of alkyl substituent. Herein, we report the first successful generally applicable conditions for the selective O-alkylation of 2(5H)-thiophenone. |
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| Keywords: | Thiophenone Mitsunobu alklyation |
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