A copper-catalyzed Petasis reaction for the synthesis of tertiary amines and amino esters |
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| Authors: | Frauenlob Robin García Carlos Bradshaw Gary A Burke Helen M Bergin Enda |
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| Affiliation: | School of Chemistry, Trinity Biomedical Sciences Institute, University of Dublin, Trinity College, Dublin 2, Ireland. |
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| Abstract: | ![]()
We have developed a copper-catalyzed process for the coupling of aldehydes, amines, and boronic acids. This allows greater reactivity with simple aryl boronic acids and allows coupling reactions to proceed that previously failed. Initial mechanistic studies support a process involving transmetalation from boron to copper. |
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