| Synthesis and Crystal Structure of 6—Bromo—piperonal—dimethyl—acetal |
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| 引用本文： | LUO Meia,MA Huai-Zhub,SU Qing-Dea①,LI Qian-Ronga a.Synthesis and Crystal Structure of 6—Bromo—piperonal—dimethyl—acetal[J].结构化学,2002,21(5):538-540. |
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| 作者姓名： | LUO Meia MA Huai-Zhub SU Qing-Dea① LI Qian-Ronga a |
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| 作者单位： | LUO Meia MA Huai-Zhub SU Qing-Dea① LI Qian-Ronga a(Department of Chemistry，University of Science and Technology of China，Hefei，Anhui 230026，China) b(Institute of Organic Chemistry，Anhui Normal University，Wuhu，Anhui 241000，China) |
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| 摘 要： | 1 INTRODUCTION 6-Bromo-piperonal-dimethyl-acetal is an intermediate used for the synthesis of natural products, such as podophyllotoxin1] and the related compounds2～6] due to the useful biological activities associated with some of its derivatives7, 8]. In particular, glycoside derivatives of 4?dimethyl- 4-epipodophyllotoxin have been used in cancer chemotherapy9, 10]. The title compound has been synthesized from raw material piperonal, after bromo substitution and acetal protection…
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| 关 键 词： | 6－溴化胡椒醛－二甲基乙缩醛 合成 晶体结构 C10H11BrO4 X射线衍射 |
Synthesis and Crystal Structure of 6-Bromo-piperonal-dimethyl-acetal |
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| LUO Mei,MA Huai-Zhu,SU Qing-De,LI Qian-Rong.Synthesis and Crystal Structure of 6-Bromo-piperonal-dimethyl-acetal[J].Chinese Journal of Structural Chemistry,2002,21(5):538-540. |
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| Authors: | LUO Mei MA Huai-Zhu SU Qing-De LI Qian-Rong |
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| Abstract: | The title compound (C10H11BrO4, Mr = 275.10) was synthesized and its crystal structure has been determined by single-crystal X-ray diffraction. The crystal is of monoclinic, space group P21/n with a = 7.2960(8), b = 12.209(1), c = 12.568(1) ? b = 98.120(2)? l = 0.71073 ? m(MoKa) = 3.700 mm-1, V = 1108.3(2) 3, Z = 4, Dc = 1.649 g/cm3 and F(000) = 552. The structure was solved by direct methods and refined by full-matrix least-squares methods. R = 0.0375 and wR = 0.0864 for 1598 reflections with I > 2s(I). X-ray diffraction reveals that there exist two rings in the molecule, and the dihedral between them is 177.5? |
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| Keywords: | 6-bromo-piperonal-dimethyl-acetal synthesis crystal structure |
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