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New synthesis of 3-fluoropyridine derivatives |
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| Authors: | William R. Dolbier Jr Yu-Lian Xu |
| Affiliation: | Department of Chemistry, University of Florida, P.O. Box 117200, Gainesville, FL 32611-7200, USA |
| Abstract: | The reaction of 2,2-bis(dimethylamino)-3,3-difluoro-1-methylcyclobutane-carbonitrile with alkyl lithiums leads to the formation of 6-alkyl-2-(dimethylamino)-3-fluoro-5-methylpyridines in moderate to good yields. |
| Keywords: | 3-Fluoropyridine derivatives [2+2] Cycloadditions Biologically active compounds |
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