Aminolysis of 6-[1-(2,6-difluorophenyl)cyclopropyl]-5-methyl-2-(nitroamino)pyrimidin-4(3H)-one |
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| Authors: | I. A. Novakov L. L. Brunilina A. A. Vernigora I. A. Kirillov A. S. Mkrtchyan M. B. Navrotskii D. S. Sheikin A. S. Yablokov E. A. Ruchko V. V. Kachala |
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| Affiliation: | 1.Volgograd State Technical University,Volgograd,Russia;2.”Pharm-Sintez” Closed Corporation,Moscow,Russia;3.Zelinskii Institute of Organic Chemistry,Russian Academy of Sciences,Moscow,Russia |
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| Abstract: | ![]()
The aminolysis of 6-[1-(2,6-difluorophenyl)cyclopropyl]-5-methyl-2-(nitroamino)pyrimidin-4(3H)-one with various amines in butan-1-ol and under solvent-free conditions is successful when the amino group in the reagent is sterically unshielded and the reaction medium is characterized by a high dielectric permittivity. Reactions of the title compound with sterically shielded amines are accompanied by alcoholysis where the amine acts as a base catalyst. |
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