| 聚乙二醇-聚乳酸共聚物药物载体 |
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| 引用本文： | 李晓然,袁晓燕.聚乙二醇-聚乳酸共聚物药物载体[J].化学进展,2007,19(6):973-981. |
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| 作者姓名： | 李晓然 袁晓燕 |
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| 作者单位： | 天津大学材料科学与工程学院,天津,300072 |
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| 摘 要： | 本文综述了聚乙二醇与聚乳酸共聚亲水改性的最新进展, 包括嵌段和星型结构聚乙二醇-聚乳酸共聚物(PEG-PLA)及其端基化衍生物的合成。同时概述了该共聚物以胶束、微粒、水凝胶和囊泡形式担载亲水、疏水及蛋白质类药物的应用，特别介绍了静电纺丝制备的PEG-PLA超细纤维载体及其释药特性。
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| 关 键 词： | 聚乙二醇-聚乳酸共聚物 药物载体 控制释放 静电纺丝 |
| 文章编号： | 1005-281X（2007）06-0973-09 |
| 收稿时间： | 2006-08 |
| 修稿时间： | 2006-082007-01 |
Poly(Ethylene Glycol)-Poly(Lactic Acid) Copolymers for Drug Carriers |
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| Li Xiaoran,Yuan Xiaoyan.Poly(Ethylene Glycol)-Poly(Lactic Acid) Copolymers for Drug Carriers[J].Progress in Chemistry,2007,19(6):973-981. |
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| Authors: | Li Xiaoran Yuan Xiaoyan |
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| Institution: | School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China |
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| Abstract: | Recent progress in hydrophilic modification of poly(lactic acid) copolymerized with poly(ethylene glycol) is reviewed in this paper. Synthesis methods of poly(ethylene glycol)-poly(lactic acid) copolymers(PEG-PLA) with block or star structures and their terminated derivatives,including their applications in loading hydrophilic,hydrophobic or protein drugs in forms of micelle,microparticle,hydrogel and vesicle are summaried.Especially,drug release behaviors of ultrafine PEG-PLA fibers prepared by electrospinning for drug carriers are introduced. |
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| Keywords: | poly(ethylene glycol)-poly(lactic acid) copolymers drug carriers controlled release electrospinning |
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