Light-assisted and remote delivery of carbon monoxide to malignant cells and tissues: Photochemotherapy in the spotlight |
| |
| Affiliation: | Department of Chemistry and Biochemistry, University of California, Santa Cruz, 1156 High St. Santa Cruz, CA 95064, United States |
| |
| Abstract: | 
The recent discovery of the salutary effects of carbon monoxide (CO) in chronic obstructive pulmonary disease (COPD), ischemic perfusion damage, graft implantation, as well as its pro-apoptotic effects on hyper-proliferating cells has raised interest in delivering small doses of CO to biological targets under controlled conditions. In such attempts, photoactive metal carbonyl complexes (photoCORMs) have shown promise and several accounts of cancer cell eradication with light-triggered CO release from photoCORMs have been reported. CO releasing molecules (CORMs) and photoCORMs have been incorporated within biocompatible drug delivery vehicles such as carboxymethyl chitosan or mesoporous silica-based nanoparticles and the composite materials (photoCORs) have been successfully employed in controlled CO delivery to cancer cells to cause rapid CO-induced apoptosis. Fiber optic technology has also been utilized for remote delivery of CO to not easily accessible targets. Reports on all these therapeutic modalities for on-demand CO delivery to malignant targets in a highly localized fashion have opened up the possibility of phototherapy of cancer with the use of an unusual so-called “toxic” molecule. This review highlights the methodologies used in CO photochemotherapy reported so far along with analysis of their therapeutic outcomes, and possible improvements for better applicability. |
| |
| Keywords: | CORM" },{" #name" :" keyword" ," $" :{" id" :" kw0010" }," $$" :[{" #name" :" text" ," _" :" CO-releasingmolecule photoCORM" },{" #name" :" keyword" ," $" :{" id" :" kw0020" }," $$" :[{" #name" :" text" ," _" :" photoactivatable CO-releasing molecule photoCOR" },{" #name" :" keyword" ," $" :{" id" :" kw0030" }," $$" :[{" #name" :" text" ," _" :" photoactivatable CO releaser COPD" },{" #name" :" keyword" ," $" :{" id" :" kw0040" }," $$" :[{" #name" :" text" ," _" :" chronic obstructive pulmonary disease NIR" },{" #name" :" keyword" ," $" :{" id" :" kw0050" }," $$" :[{" #name" :" text" ," _" :" near infrared MLCT" },{" #name" :" keyword" ," $" :{" id" :" kw0060" }," $$" :[{" #name" :" text" ," _" :" metal-to-ligand charge transfer ROS" },{" #name" :" keyword" ," $" :{" id" :" kw0070" }," $$" :[{" #name" :" text" ," _" :" reactive oxygen species MTT" },{" #name" :" keyword" ," $" :{" id" :" kw0080" }," $$" :[{" #name" :" text" ," _" :" 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide AO/EB" },{" #name" :" keyword" ," $" :{" id" :" kw0090" }," $$" :[{" #name" :" text" ," _" :" acridine orange/ethidium bromide CBS" },{" #name" :" keyword" ," $" :{" id" :" kw0100" }," $$" :[{" #name" :" text" ," _" :" cystathionine-β-synthase GSH" },{" #name" :" keyword" ," $" :{" id" :" kw0110" }," $$" :[{" #name" :" text" ," _" :" glutathione PEG" },{" #name" :" keyword" ," $" :{" id" :" kw0120" }," $$" :[{" #name" :" text" ," _" :" polyethylene glycol EPR" },{" #name" :" keyword" ," $" :{" id" :" kw0130" }," $$" :[{" #name" :" text" ," _" :" enhanced permeability and retention pHEMA" },{" #name" :" keyword" ," $" :{" id" :" kw0140" }," $$" :[{" #name" :" text" ," _" :" poly(2-hydroxyethyl methacrylate) PBNP" },{" #name" :" keyword" ," $" :{" id" :" kw0150" }," $$" :[{" #name" :" text" ," _" :" Prussian blue nanoparticles |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
