Recent advances in short peptide self-assembly: from rational design to novel applications |
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| Institution: | 1. Biological Physics Group, School of Physics and Astronomy, University of Manchester, Oxford Road, Manchester, M13 9PL, UK;2. Photon Science Institute, University of Manchester, Oxford Rd., Manchester, M13 9PL, UK;1. School of Chemistry, University of Bristol, Cantock’s Close, Bristol BS8 1TS, UK;2. School of Biochemistry, University of Bristol, Medical Sciences Building, University Walk, Bristol BS8 1TD, UK;3. BrisSynBio, University of Bristol, Life Sciences Building, Tyndall Avenue, Bristol BS8 1TQ, UK;1. State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, 100029 Beijing, China;2. Chair of Materials Science, Otto Schott Institute of Materials Research, Friedrich Schiller University Jena, Löbdergraben 32, 07743 Jena, Germany;3. Jena Center for Soft Matter (JCSM), Friedrich Schiller University Jena, Philosophenweg 7, 07743 Jena, Germany;4. Jena School for Microbial Communication (JSMC), Neugasse 23, 07743 Jena, Germany;5. Faculty of Production Engineering, University of Bremen, D-28359 Bremen, Germany;1. Centre for Bioengineering and Biotechnology, China University of Petroleum (East China), Qingdao 266580, China;2. Biological Physics Group, School of Physics and Astronomy, University of Manchester, Schuster Building, Oxford Road, Manchester M13 9PL, United Kingdom;3. ISIS Pulsed Neutron Source, Rutherford Appleton Laboratory, Didcot, Oxon OX11 0QZ, United Kingdom;1. Division of Biomedical Engineering, Division of Renal Medicine, Brigham and Women''s Hospital, Harvard Medical School, Boston, MA 02139, USA;2. Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women''s Hospital, Harvard Medical School, Boston, MA 02115, USA;3. Center for Nanotechnology, King Abdulaziz University, Jeddah 21589, Saudi Arabia;1. Department of Chemistry, Brandeis University, 415 South Street, Waltham, MA 02453, USA |
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| Abstract: | Owing to their structural simplicity and robust self-assembled nanostructures, short peptides prove to be an ideal system to explore the physical processes of self-assembly, hydrogels, semi-flexible polymers, quenched disorder, and reptation. Rational design in peptide sequences facilitates cost-effective manufacturing, but the huge number of possible peptides has imposed obstacles for their characterization to establish functional connections to the primary, secondary, and tertiary structures. This review aims to cover recent advances in the self-assembly of designed short peptides, with a focus on physical driving forces, design rules, characterization methods, and exemplar applications. Super-resolution microscopy in combination with modern image analysis have been applied to quantify the structure and dynamics of peptide hydrogels, while small-angle neutron scattering and solid-state nuclear magnetic resonance continue to provide valuable information on structures over complementary length scales. Short peptides are attractive in biomedicine and nanotechnology, e.g., as antimicrobials, anticancer agents, vehicles for controlled drug release, peptide bioelectronics, and responsive cell culture materials. |
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| Keywords: | Short peptides Self-assembly Non-covalent interactions Molecular design Nanostructures Characterization techniques STORM SANS Hydrogels |
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