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Synthese von 1-Ary1-4-methylthio-2-azetidinonen |
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| Authors: | Alexander Wiatschka Karl-Hans Ongania |
| Institution: | (1) Institut für Organische und Pharmazeutische Chemie, Universität Innsbruck, A-6020 Innsbruck, Österreich |
| Abstract: | TheN-arylthioformimidates4 a-e, which may be obtained byS-alkylation of the thioformanilides3 a-e, react with chloroacetylchloride/triethylamine to yield the (3R,4S/3S,4R)-1-aryl-3-chloro-4-methylthio-2-azetidinones5 a-e and the formanilides6 a-e. Dehalogenation of5 b-e with tri-n-butyltinhydride yield the title compounds7 b-e. Hydrogenolysis of7 b and7 c yields7 f and7 g. |
| Keywords: | 1-Aryl-3-chloro-4-methylthio-2-azetidinones 1-Aryl-4-methylthio-2-azetidinones Dehalogenation N-Arylthioformimidates Tri-n-butyl tinhydride |
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