Cascade cyclization reactions of 3,4,5-triamino-1,2,4-triazole with aromatic aldehydes and cycloalkanones |
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| Authors: | V V Lipson S M Desenko V V Borodina M G Shirobokova O V Shishkin R I Zubatyuk |
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| Institution: | (1) V. Ya. Danilevsky Institute of Endocrine Pathology Problems, Academy of Medical Sciences of the Ukraine, 10 ul. Artema, 61002 Kharkov, Ukraine;(2) State Scientific Institution Scientific and Technological Corporation “Institute for Single Crystals”, National Academy of Sciences of the Ukraine, 60 prosp. Lenina, 61001 Kharkov, Ukraine |
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| Abstract: | A three-component condensation of 3,4,5-triamino-1,2,4-triazole (1) with aromatic aldehydes 2a–f and dimedone (3) or cyclohexanone (8) afforded partially hydrogenated 9-aryl-1,2,4]triazolo5,1-b]quinazolin-8-ones. The structure of 2-amino-6,6-dimethyl-3-(4-nitrobenzylidene)amino-9-(4-nitrophenyl)-5,6,7,9-tetrahydro1,2,4]triazolo5,1-b]quinazolin-8-one (4e) was confirmed by X-ray diffraction data.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 7, pp. 1178–1182, July, 2006. |
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| Keywords: | 3 4 5-triamino-1 2 4-triazole aromatic aldehydes dimedone cyclohexanone partially hydrogenated [1 2 4]triazolo[5 1-b]quinazolines synthesis X-ray diffraction analysis |
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