PHOTOACTIVE TERTHIOPHENES: THE INFLUENCE OF SERUM ON ANTI-HIV (HUMAN IMMUNODEFICIENCY VIRUS) ACTIVITIES |
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| Authors: | Kenjiro Yoshimura |
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| Affiliation: | Department of Pathology and Laboratory Medicine, University of British Columbia, 2733 Heather Street, Vancouver, BC V5Z IM9;Provincial AIDS Laboratory, Vancouver, BC;Department of Botany, Brandon University, Brandon, Manitoba, R7A 6A9;Ottawa-Carleton Institute of Biology, University of Ottawa, Ottawa, Ontario KIN 6N5, Canada |
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| Abstract: | ![]()
Abstract-A number of carboxylic acid derivatives of the photoactive terthiophene, α-terthienyl, were found to possess impressive UVA-dependent activity against the human immunodeficiency virus, HIV-1; but only when assayed in the absence of serum, indicating that the latter contained interfering components. Good antiviral activity required a high rate of singlet oxygen production, in accordance with previous observations on thiophenes. |
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