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Access to original spirocyclic derivatives via inter- or intramolecular reaction mediated by manganese(III) acetate |
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| Authors: | Ahlem Bouhlel Christophe Curti Michèle P Bertrand Patrice Vanelle |
| Institution: | 1. Aix-Marseille Univ, CNRS, Institut de Chimie Radicalaire ICR, UMR 7273, Laboratoire de Pharmaco-Chimie Radicalaire, Faculté de Pharmacie, 27 Bd Jean Moulin, CS 30064, 13385 Marseille Cedex 05, France;2. Aix-Marseille Univ, CNRS, Institut de Chimie Radicalaire ICR, UMR 7273, Laboratoire de Chimie Moléculaire Organique, Faculté des Sciences et Techniques de Saint Jérôme, Avenue Normandie-Niemen, 13397 Marseille Cedex 20, France |
| Abstract: | An easily reproducible protocol allowing inter- or intramolecular spirocyclization on β-dicarbonyl structures is described. This methodology could afford a wide variety of spirocyclic pharmacophores. As examples, highly substituted spirobenzophenanthridin-6(5H)-ones and spirolactones were synthesized. These scaffolds could be used for the design of many compounds exhibiting biological activities. |
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